Transitional points in patient care, such as handoffs and hospital discharges, are known to have unique information challenges. Transitions following long-term care involve even more complex processes. In this study, we examine the informational and contextual issues for patients transitioning from the care of specialists who have come to know them through long-term partnerships to clinicians potentially less familiar with patients’ chronic care concerns. The context is bone marrow transplant (BMT); specifically allogeneic transplants, which involve risk for particular chronic complications and a long-term process that requires close monitoring of patients by BMT specialists for at least a year beyond the actual transplant procedure. Based on a 16-month field study, we examine patient experience and clinician viewpoints regarding the transition of patient responsibility from BMT clinicians to primary care or oncologists, and detail the important issues for patients and clinicians.